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Arteries and veins transport blood through the body, including to the eyes. Each retina has one central artery and one central vein. Retinal Vein Occlusion (RVO) happens when blood and fluid don’t effectively drain from the eye.

What is retinal vein occlusion (RVO)?

When veins in the eye are blocked by a blood clot there can be resulting damage to the eye. Bleeding and fluid leaks can damage the macula or retina and lead to vision problems and poor ocular blood circulation. RVO generally occurs only in one eye because it is typically not a systemic condition. RVO can develop in the central vein (CRVO) or in branch veins (BRVO) of the retina.¹

Macular edema following RVO (MEfRVO)

Blocked blood vessels can cause fluid to leak into the center of the retina, called the macula. The swelling is called Macular Edema following Retinal Vein Occlusion, or MEfRVO.¹ This condition can lead to vison loss.

Risk factors for MEfRVO

Risk factors for developing MEfRVO include^1-3:

• Age (over 50)
• Being overweight or obese
• High blood pressure (particularly when uncontrolled)
• Smoking

Types of MEfRVO

Just like there are two types of RVO, there are two types of MEfRVO:

1. Macular Edema following Central Retinal Vein Occlusion (MEfCRVO)
2. Macular Edema following Branch Retinal Vein Occlusion (MEfBRVO)

Central retinal vein occlusion (CRVO)

CRVO develops when there is a blockage in the central retinal vein, the main vein that transports oxygen and nutrients away from the nerve cells in the retina and drains blood from the eye.²

Types of CRVO

1. Non-ischemic CRVO, a less serious form, represents about 75% of cases, and generally has better outcomes.
2. Ischemic CRVO, the more serious type, can lead to vision loss and even the loss of an eye.²

Symptoms of CRVO

Symptoms of CRVO can sometimes be difficult to recognize, and the condition may happen suddenly.^1,2 They include:

• Sudden loss or blurring of vision (over several hours or days)
• Sudden loss of all vision
• Dark spots or little squiggles in vision (floaters)

Severe central retinal vein occlusion (CRVO) in people with glaucoma may cause pain, redness, or irritation.

Macular edema following CRVO (MEfCRVO)

MEfCRVO develops when a blockage causes fluid to leak into the macula. 20% of RVO cases are diagnosed as CRVO.¹ Symptoms can be mild, even undetectable. Some people experience blurry or distorted vision caused by swelling of the center part of the retina. Disturbances to vision can come and go, these are called visual observations.

Branch retinal vein occlusion (BRVO)

When branches of the retinal vein become blocked, it is called branch retinal vein occlusion. BRVO occurs when one or more veins branching out from the central retinal vein become blocked. 80% of RVO cases are BRVO. MEfBRVO occurs when fluid leaks into the macula as a result of a blocked retinal vein.

Macular edema following BRVO

BRVO can cause a sudden yet pain-free loss of vision. If the impacted area is not in the center of the eye, BRVO can go undetected by having no visual symptoms.³ Blood clotting due to compression of the vein can happen in people with atherosclerosis, a hardening of the arteries, causing the artery to lose flexibility. This can cause a blockage due to changes in blood flow resulting in leakage of fluid into the center of vision (macular edema) and ischemia, which is poor flow through the vessels (perfusion).³

How is retinal vein occlusion diagnosed?

Both CRVO and BRVO are diagnosed by an ophthalmologist or retina specialist during an eye exam. CRVO is diagnosed through an evaluation of medical signs and patient-reported symptoms. It is characterized by a pattern of retinal hemorrhages (bleeding). In a BRVO exam the doctor may use Fluorescein angiography (FA) or Optical Coherence Tomography (OCT). Those are imaging tools which allow doctors to see a retinal hemorrhage where the blood vessels have leaked into the retina), thickened and twisted blood vessels, and retinal edema (swollen with fluid).3

How is retinal vein occlusion treated?

Assessing underlying risks is the first step in assessing macular edema. Monitoring blood pressure, cholesterol/lipid levels, and blood clotting tendencies all can reduce the likelihood of advancing disease. Managing complications rather than trying to remove blockages is the primary treatment approach.

Anti-VEGF therapy

With both MEfCRVO and MEfBRVO patients may receive injections into the eye with anti-VEGF drugs which inhibit the abnormal growth of blood vessels and decrease leakage in the eye. Sometimes called Intravitreal therapy, these drugs have been proven effective to reduce swelling which improves vision, but they are not a cure. There are 3 anti-VEGF drugs with brand names Avastin, Lucentis, and Eylea. All have demonstrated success with visual improvement in more than 50% of patients in clinical trials.

Laser therapy

Laser therapy is another approach for managing macular edema, it is used less often but can have a more permanent effect. A third, less common approach is intraocular injections of steroids; these are sometimes used in people where anti-VEGF drugs have been ineffective.

Prognosis for retinal vein occlusion

The prognosis is generally good for BRVO with many people requiring no interventions. The prognosis for CRVO is generally better in younger people than older people who may have had an undetected condition for a longer period of time.^2,3

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What are Drusen?

Which Mac operating system is the best is a topic of numerous debates among Apple fans.

Since the mission of this blog is to refute myths and legends around Macs, it’s time for me to provide my 2 cents about the issue on hand. While everything below is just my opinion, as a long-time Mac user and veteran software engineer, I hope my opinion worth something.

The best Mac OS version is the one that your Mac is eligible to upgrade to. In 2021 it is macOS Big Sur. However, for users that need to run 32-bit apps on Mac, the best macOS is Mojave. Also, older Macs would benefit if upgraded at least to macOS Sierra for which Apple still releases security patches.

How to Tell Which macOS You Are Running

To find out which macOS is currently running on your Mac, follow these steps:

1. Click on Apple logo in the top left corner of the menubar
2. In the dropdown click on the first item: About This Mac
3. The first line in the Overview tab is the name of the current OS.

What Version of OS Can My Mac Run?

Not all Macs can be upgraded to the latest OS version. For instance, old Macs powered by PowerPC CPUs cannot run OS intended for Intel-based computers. Also, some versions have hardware limitations.

For instance, Mojave cannot be installed on MacBook Pro earlier than Mid 2012 model.

Check below to know exactly what version of OS your Mac can run.

Which OS is Best for my Mac

Anytime someone asks me which OS is best for them I always suggested going with the latest. Things have changed recently, however.

Should I Upgrade to macOS Catalina or Big Sur?

While personally I like macOS Big Sur and have it installed on my MacBook Pro, it comes with serious breaking changes.

The first issue is compatibility.

Big Sur is a transition OS which is designed to help Apple to move from Intel processors to their own chips on ARM.

After I installed Big Sur on my MacBook Pro mid 2020 (pre-Silicon), most of my apps, including Microsoft Office, were working as expected.

However, my VMWare Fusion 11 does not start anymore, so I have to purchase a new license if I want to keep using it (or roll back to Catalina). Luckily, I took a full backup before the upgrade.

The second breaking issue is the lack of 32-bit app support.

macOS Catalina and Big Sur can only run 64-bit apps.

If you wondering whether you should upgrade to macOS Catalina or Big Sur, first verify that you don’t have any 32-bit apps. But first, take a back up, so you can go back in case something breaks after the upgrade.

For instance, I had to remove uTorrent after upgrade. And I didn’t know that uTorrent is 32-bit!

How to Know If App is 32-bit or 64-bit

To find out whether the app on your Mac is 32-bit or 64-bit follow these steps:

1. Click on Apple logo in the top left corner of the Mac screen
2. Click on About This Mac option
3. Click on System Report button in Overview tab (first one)
4. Scroll down to Software -> Applications
5. Find the app and check Kind

Which macOS Should I Use

If you have an older Mac which is not eligible to upgrade with some latest software or hardware, I’d suggest upgrading at least to Sierra (or better High Sierra) for the following reasons:

• Sierra is still supported by Apple, and it gets security updates
• APFS file system is available
• It supports Siri
• Significant security improvements

The most important point when choosing the best OS is the ability to get security updates. While Apple generally does not announce the OS end of life dates, it is possible to know when they stop releasing security updates from this page.

For instance, according to the page, the last security update for OS X Yosemite was released on September 12, 2017. The last update for OS X El Capitan was in July 2018, and Carnegie Mellon University confirmed that El Capitan’s end of life date was August 2018.

Snow Leopard Myth

I know that some users on forums believe that the best OS version for Macs was Snow Leopard. But that is a myth. And I know how such myths get created.

Once I worked in the company, which was selling a 20-year old product. And customers were still using and didn’t want to switch to new versions, because the old one was rock solid.

I then talked to the engineer who worked on the project, and he revealed that the product was a total disaster when it was first deployed. Engineers had to work on-site for almost a year in order to fix all bugs.

After five or so years of polishing the product, it becomes virtually bug-free, and nobody now remembers how bad it was when it was first rolled out. A similar thing happened Snow Leopard, and it was recognized as best mac os version after some time.

How to Update to the Latest Version

There are two ways to update to the latest OS version on Mac:

• From the Software Update section in System Preferences
• Use a download link

Using Software Update

This is by far the best option, but it only available if you have Yosemite, or later OS installed already. If you enabled automatic updates, then Mac will inform you that the next macOS is available.

Just open System Preferences, go to Software Update and click on the Upgrade Now button.

This method is also best if wondering how to check if you have the latest version of OS installed on your Mac. Only the version compatible with your hardware will appear here.

For instance, my the latest version for Mac Mini 2012 is Mojave, I can’t install anything newer than that.

If you are having problems with updates or having issues post-upgrade check my post about troubleshooting macOS.

Using download links

For older systems or in case you need to downgrade, you have to download a standalone installer in DMG format. DMG stands for disk image, similar to ISO, just different formats.

After downloading the installer, just double click on it and follow instructions. Again, do not forget to take a backup before the upgrade.

Mac OS Comparisons: Requirements, Features, Compatibility, Download Links

Following is a high-level description of all Mac operating systems as early as Mountain Lion.

You can refer to those descriptions when deciding which operating system is best for your iMac, Mac Pro, Mac mini, or MacBook.

With each OS description, I included a list of Macs supported. However, you can use Mac OS compatibility checker for more detailed information.

macOS 11 Big Sur

macOS v11 (codename Big Sur) is the latest version of the operating system for Apple computers.

Release date: October 13, 2020

Hardware Requirements: RAM requirement 4GB. Big Sur is the first OS to support new Macs using ARM technology (in the future).

Features

• The biggest design refresh since macOS X.
• Support for new ARM processors.
• Safar improved performance and power consumption.
• Time Machine supports backup to APFS volumes.
• One-click translation for 7 languages.
• Redesigned maps

Software Compatibility Issues

Only 64-bit apps are allowed to run on Big Sur.

Veins Of Light Mac Os Update

How to install

There are two ways to install Big Sur: enable automatic updates in System Preferences or download by using the following link.

Or check my post with tips on installing macOS on unsupported devices.

List of Apple computers compatible with macOS Big Sur

• MacBook (2015 and later)
• MacBook Air (2013 and later)
• MacBook Pro (2013 and later)
• Mac mini (2014 and later)
• iMac models (2014 and later)
• iMac Pro (2017 and later)
• Mac Pro (2013 and later)

macOS 10.15 Catalina

Release date: October 7, 2019

Hardware Requirements: RAM requirement increased from 2GB to 4GB.

Features

• Introduced Sidecar, which allows for Macs to use an iPad as an external display.
• iTunes was replaced by separate apps: Music, Podcasts, and TV.
• Find My Mac and Find My Friends have merged into one app.

Software Compatibility Issues

macOS Catalina is the first Mac operating system that does not support 32-bit applications. Only 64-bit apps are allowed to run on Catalina.

How to install

There are two ways to install Catalina: enable automatic updates in System Preferences or download by using the following link.

List of Apple computers compatible with macOS Catalina

• MacBook (Early 2015 or later)
• MacBook Air (Mid 2012 or later)
• MacBook Pro (Mid 2012 or later)
• Mac mini (Late 2012 or later)
• iMac models (Late 2012 or later)
• iMac Pro (All models)
• Mac Pro (Late 2013)

macOS 10.14 Mojave

Release date: September 24, 2018

Hardware Requirements: 2GB RAM and 18.5GB free space on disk

Features

• The main feature of Mojave is “Dark Mode”
• FaceTime adds group feature which allows chatting with up to 32 people
• News, Stocks, Voice Memos, and Home apps were ported from iOS to Mac.

How to install

If your Mac is eligible to update to Mojave, then the easiest way to install it is by enabling automatic updates. Downloading a standalone Mojave installer could be a little tricky.

List of Apple computers compatible with macOS Mojave

• MacBook (Early 2015 or later)
• MacBook Air (Mid 2012 or later)
• MacBook Pro (Mid 2012 or later)
• Mac mini (Late 2012 or later)
• iMac (Late 2012 or later)
• iMac Pro (All models)
• Mac Pro (Late 2013 and 2010-2012 models with upgraded GPU)

macOS 10.13 High Sierra

Release date: September 25, 2017

Hardware Requirements: 2GB RAM and 14.3GB free space on disk

Features

• APFS (Apple File System) becomes the default file system in High Sierra. It’s a significant upgrade from the older HFS+ in terms of speed, size, and security
• iCloud support of Messages which allows sync messages of the account across multiple devices
• Mail app uses 35% less storage space due to optimizations

List of Apple computers compatible with macOS High Sierra

• MacBook (Late 2009 or newer)
• MacBook Pro (Mid 2010 or newer)
• MacBook Air (Late 2010 or newer)
• Mac mini (Mid 2010 or newer)
• iMac (Late 2009 or newer)
• Mac Pro (Mid 2010 or newer)

How to install

Here is a High Sierra download link.

macOS 10.12 Sierra

This is the first macOS version. Previous OS versions for Macs were called OS X (X stands for 10).

Release date: September 20, 2016

Hardware Requirements: 2GB RAM and 8GB free space on disk

Features

• Siri was introduced to Macs
• Optimized storage with iCloud sync
• Auto-lock feature allows unlocking MacBook with paired Apple Watch
• APFS preview available
• Disk Utility can manage RAID sets again
• Significant security improvements

How to install

Here is a Sierra download link.

List of Apple computers compatible with macOS Sierra

• MacBook (Late 2009 or newer)
• MacBook Pro (Mid 2010 or newer)
• MacBook Air (Late 2010 or newer)
• Mac mini (Mid 2010 or newer)
• iMac (Late 2009 or newer)
• Mac Pro (Mid 2010 or newer)

OS X 10.11 El Capitan

Last OS X version.

Release date: September 30, 2015

Hardware Requirements: 2GB RAM and 8GB free space on disk

Features

• System Integrity Protection – a security feature that protects even when the root user executes the process
• Performance improvements: open PDF files four times faster, Mail is twice faster, launching apps 40% faster
• Notes app similar to the app in iOS

Macs compatible with OS X El Capitan

same as OS Mountain Lion.

How to install

Here is El Capitan download link.

OS X 10.10 Yosemite

Release date: October 16, 2014

Hardware Requirements: 2GB RAM and 8GB free space on disk

Macs compatible with OS X Yosemite

Same as OS Mountain Lion.

Features

Veins Of Light Mac Os 8

• Major user design overhaul
• Introduction of Handoff and Continuity features
• Photos app replaced iPhoto and Aperture

How to install

Here is Yosemite download link.

OS X 10.9 Mavericks

First free Mac OS. Previous OS versions vary from $19.99 to $129.

Release date: October 22, 2013

Hardware Requirements: 2GB RAM and 8GB free space on disk

Features

• Compressed Memory feature automatically compresses inactive apps when approaching maximum memory capacity
• Timer coalescing is a feature that reduces CPU usage by up to 72 percent
• App Nap puts apps that are not currently visible to sleep

Macs compatible with OS X Mavericks

Same as OS Mountain Lion.

How to install

OS X Mavericks installer is not available on Apple Site. Follow instructions here to install Mavericks.

OS X 10.8 Mountain Lion

Must be purchased. Fixed many bugs introduced in OS X Lion.

Release date: July 25, 2012

System Requirements: 2GB RAM and 8GB free space on disk

Features

• New apps: Notification Center, Notes, Messages, Game Center
• AirPlay mirroring allowed to mirror Mac screen to Apple TV
• Application updates automatically install from the App Store

List of Apple computers compatible with OS X Mountain Lion

• iMac (Mid-2007 or newer)
• MacBook (Late 2008 Aluminum, or Early 2009 or newer)
• MacBook Air (Late 2008 or newer)
• MacBook Pro (Mid/Late 2007 or newer)
• Mac mini (Early 2009 or newer)
• Mac Pro (Early 2008 or newer)
• Xserve (Early 2009)

How to install

Mountain Lion installer is not available on Apple Site. Follow instructions here to install OS X Mountain Lion.

List of older Mac OS Versions

Following Mac OS versions are still running on older Macs, but Apple does not support them anymore, and there is no point to upgrade (or downgrade) to them:

• OS X 10.7 Lion
• OS X 10.6 Snow Leopard
• Mac OS X 10.5 Leopard
• Mac OS X 10.4 Tiger
• Mac OS X 10.3 Panther
• Mac OS X 10.2 Jaguar
• Mac OS X 10.1 Puma
• Mac OS X 10.0 Cheetah

Veins Of Light Mac OS